Written by the Fiveable Content Team • Last updated September 2025
Verified for the 2026 exam
Verified for the 2026 exam•Written by the Fiveable Content Team • Last updated September 2025
Definition
Small RNA molecules are short fragments of RNA that play crucial roles in regulating gene expression, among other functions.
Related terms
siRNA (Small Interfering RNA): These small RNAs interfere with the expression of specific genes with complementary nucleotide sequences by degrading mRNA after transcription, preventing translation. They're like traffic cops specifically tasked with stopping certain cars from moving forward.
piRNA (Piwi-interacting RNA): These small RNAs interact with piwi proteins and play a role in maintaining genome stability, especially in germ cells. They're like traffic cops who also check the cars' (genes') condition to ensure they're roadworthy.
This type of small RNA molecule helps decode a messenger RNA (mRNA) sequence into a protein. It's like the traffic cop that helps guide cars onto the right highway exit to reach their destination.