Non-Competitive Inhibitors

Definition

Non-competitive inhibitors are molecules that bind to an allosteric site on an enzyme, causing a conformational change in the enzyme's active site. This prevents the substrate from binding effectively, reducing enzymatic activity.

Related terms

Enzyme kinetics: The study of how enzymes catalyze chemical reactions, including the effects of inhibitors on enzyme activity.

Feedback inhibition: A regulatory mechanism in which the end product of a metabolic pathway acts as a non-competitive inhibitor of an earlier enzyme in the pathway, slowing down its own production.

Enzyme-substrate complex: The temporary complex formed when an enzyme binds to its substrate(s) during a chemical reaction.