Cofactor:A non-protein chemical compound required for an enzyme's activity. Like how basketball players need shoes to perform their best.
Coenzyme: A small molecule (not a protein but sometimes a vitamin) essential for the activity of some enzymes. Like how athletes need water during games to stay hydrated and perform optimally.
Allosteric activator: A substance that binds to an enzyme to change its shape and increase its ability to bind substrates. Imagine if cheering could physically make athletes stronger!