💀anatomy and physiology i review

Sciatic nerve

Written by the Fiveable Content Team • Last updated September 2025
Written by the Fiveable Content Team • Last updated September 2025

Definition

The sciatic nerve is the largest and longest nerve in the human body, running from the lower back through the buttocks and down each leg, responsible for sensory and motor functions in the thigh, knee, calf, ankle, foot, and toes. It plays a crucial role in connecting the spinal cord with the skin and muscles of the thigh, leg, and foot.

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