Persistent low mood refers to a continuous and prolonged state of feeling sad, hopeless, or disinterested in life, which significantly impacts daily functioning. This mood state is a core feature of both Major Depressive Disorder and Persistent Depressive Disorder, where individuals experience emotional distress that hinders their ability to engage in activities they once enjoyed, often accompanied by other symptoms such as changes in sleep patterns, appetite, and energy levels. Understanding this term helps highlight the severity and duration of depressive episodes within these disorders.