Mast cell

Definition

Mast cells are immune cells found in connective tissues, especially in the skin, lungs, and digestive tract. They play a crucial role in the body's allergic and inflammatory responses by releasing histamines and other chemicals.

5 Must Know Facts For Your Next Test

1. Mast cells originate from bone marrow and mature in various tissues.
2. They contain granules rich in histamine, heparin, and other mediators of inflammation.
3. Upon activation, mast cells release their granules into the extracellular environment, contributing to inflammatory responses.
4. Mast cells are involved in both immediate hypersensitivity reactions (such as anaphylaxis) and chronic inflammatory conditions.
5. The activation of mast cells can be triggered by allergens binding to IgE antibodies on their surface.

Related terms

Histamine:

A compound released by mast cells that causes vasodilation and increased permeability of blood vessels during allergic reactions.

IgE Antibodies: Immunoglobulin E antibodies that bind to allergens and trigger mast cell activation.

Anaphylaxis:

A severe, potentially life-threatening allergic reaction involving widespread mast cell degranulation.