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Dipeptidase

Written by the Fiveable Content Team • Last updated August 2025
Written by the Fiveable Content Team • Last updated August 2025

Definition

Dipeptidase is an enzyme that breaks down dipeptides into individual amino acids. It is essential for the final stage of protein digestion in the small intestine.

5 Must Know Facts For Your Next Test

  1. Dipeptidase is located on the brush border of the small intestine.
  2. It specifically targets dipeptides, which are molecules composed of two amino acids linked by a single peptide bond.
  3. The activity of dipeptidase ensures that proteins are fully broken down into absorbable amino acids.
  4. A deficiency in dipeptidase can lead to incomplete digestion and absorption of proteins, causing nutritional deficiencies.
  5. Dipeptidases work optimally at the slightly alkaline pH found in the small intestine.

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