Positive selection

Definition

Positive selection is a critical process during the development of T lymphocytes (T cells) in the thymus, where immature T cells that can properly recognize self-MHC (Major Histocompatibility Complex) molecules are selected to survive and mature. This ensures that the immune system can effectively recognize and respond to pathogens without attacking the body's own cells.

Related terms

T lymphocytes:

White blood cells that play a crucial role in the adaptive immune response, including identifying and eliminating pathogens.

Major Histocompatibility Complex (MHC):

A set of cell surface proteins essential for the acquired immune system to recognize foreign molecules in vertebrates, thereby helping determine which cells are self or non-self.

Negative Selection:

A process in which T cells that bind too strongly to self-MHC molecules are induced to die, preventing autoimmune responses