Negative selection

Definition

Negative selection is a process in the thymus where developing T lymphocytes (T cells) that strongly react against self-antigens are induced to die, ensuring that these self-reactive T cells do not enter the circulation. This mechanism is crucial for preventing autoimmune diseases by eliminating potential auto-reactive T cells during the development of the adaptive immune response.

Related terms

Autoimmunity: A condition where the immune system mistakenly identifies and attacks the body's own tissues as if they were foreign invaders.

Thymus:

A primary lymphoid organ where T lymphocytes mature and undergo processes such as negative selection.

Antigen: Any substance that induces an immune response, including parts of pathogens like bacteria or viruses, as well as non-infectious substances