🥼organic chemistry review

Steric strain

Written by the Fiveable Content Team • Last updated August 2025
Written by the Fiveable Content Team • Last updated August 2025

Definition

Steric strain is the repulsion between adjacent atoms or groups in a molecule due to their physical size, causing a decrease in stability. This strain affects the molecule's spatial configuration and can influence its reactivity.

AP course connection

Topic 4.5: 4.5 Conformations of Cyclohexane

Unit 4
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