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Ribulose bisphosphate carboxylase (RuBisCO)

Written by the Fiveable Content Team • Last updated August 2025
Written by the Fiveable Content Team • Last updated August 2025

Definition

Ribulose bisphosphate carboxylase (RuBisCO) is an enzyme involved in the first major step of carbon fixation in the Calvin cycle of photosynthesis. It catalyzes the reaction between ribulose-1,5-bisphosphate (RuBP) and carbon dioxide to form two molecules of 3-phosphoglycerate.

5 Must Know Facts For Your Next Test

  1. RuBisCO is considered one of the most abundant proteins on Earth due to its crucial role in photosynthesis.
  2. The enzyme has both carboxylase and oxygenase activity, which can lead to photorespiration when it reacts with oxygen instead of carbon dioxide.
  3. RuBisCO's efficiency is relatively low, leading plants to produce it in large quantities to meet metabolic demands.
  4. It requires magnesium ions (Mg2+) for its catalytic activity and proper function.
  5. The enzyme operates optimally at a specific pH range, usually around pH 8.0, which is maintained by the stroma of chloroplasts.
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