Written by the Fiveable Content Team • Last updated August 2025
Written by the Fiveable Content Team • Last updated August 2025
Definition
Reye syndrome is a rare but serious condition that causes swelling in the liver and brain. It most commonly affects children and teenagers recovering from a viral infection, often the flu or chickenpox.
Reye syndrome is often associated with aspirin use during viral infections such as influenza or varicella.
Symptoms of Reye syndrome include persistent vomiting, confusion, seizures, and loss of consciousness.
Early diagnosis and treatment are crucial to prevent severe complications like brain damage or death.
The exact cause of Reye syndrome is unknown, but it involves mitochondrial damage leading to cellular dysfunction.
Laboratory findings typically include elevated liver enzymes, hyperammonemia, and hypoglycemia.
Related terms
Aspirin: A medication used to reduce pain, fever, or inflammation; associated with triggering Reye syndrome when given to children during viral infections.