Goblet cell

Definition

Goblet cells are specialized epithelial cells found in the respiratory and intestinal tracts, responsible for secreting mucus to protect and lubricate the lining. They play a crucial role in maintaining the mucosal barrier against pathogens.

5 Must Know Facts For Your Next Test

1. Goblet cells secrete mucus containing glycoproteins called mucins which trap and eliminate pathogens from the respiratory tract.
2. They are predominantly found in the trachea, bronchi, and larger bronchioles of the respiratory system.
3. Chronic respiratory infections can lead to an increase in goblet cell number and mucus production, often observed in conditions like chronic bronchitis.
4. The mucus secreted by goblet cells also contains antimicrobial peptides that provide an additional defense against microbial invasion.
5. Goblet cell dysfunction or depletion can contribute to impaired mucociliary clearance, increasing susceptibility to respiratory infections.

Related terms

Mucociliary Clearance:

A mechanism involving cilia and mucus to remove inhaled particles from the lungs.

Mucins: Glycoproteins secreted by goblet cells that form a major component of mucus.

Bronchial Epithelium: The lining of the bronchi consisting of various cell types including ciliated cells and goblet cells.