Fusion inhibitors

Definition

Fusion inhibitors are a class of antiviral drugs that prevent viruses from entering host cells by blocking the fusion of the viral and cellular membranes. They are primarily used in the treatment of HIV.

5 Must Know Facts For Your Next Test

1. Fusion inhibitors interfere with the early stage of viral replication.
2. They target the interaction between viral proteins and host cell receptors.
3. Enfuvirtide is a well-known example of a fusion inhibitor used to treat HIV.
4. These drugs are typically administered via injection due to their peptide nature.
5. Resistance to fusion inhibitors can develop, often requiring combination therapy with other antiretrovirals.

Related terms

Antiretroviral: Drugs used to manage and treat HIV/AIDS by inhibiting various stages of the virus life cycle.

Protease Inhibitors:

A class of antiviral drugs that prevent viral replication by inhibiting the protease enzyme.

Entry Inhibitors: Antiviral drugs that block viruses from entering host cells, similar to fusion inhibitors but often targeting different mechanisms or stages.