🦠microbiology review

Fulminant hepatitis

Written by the Fiveable Content Team • Last updated August 2025
Written by the Fiveable Content Team • Last updated August 2025

Definition

Fulminant hepatitis is a severe and sudden liver failure caused by rapid liver cell death, often due to viral infections like hepatitis B or C. It leads to coagulopathy, encephalopathy, and can be life-threatening.

5 Must Know Facts For Your Next Test

  1. Fulminant hepatitis is characterized by the rapid onset of liver failure within 8 weeks of the initial symptoms of liver disease.
  2. Common causes include viral infections such as hepatitis B and C, as well as toxins, drugs, and autoimmune diseases.
  3. Symptoms include jaundice, confusion (hepatic encephalopathy), bleeding tendencies (coagulopathy), and multi-organ failure.
  4. Diagnostic tools include blood tests showing elevated liver enzymes and bilirubin levels, as well as imaging studies like ultrasound or CT scans.
  5. Treatment options are limited; they focus on managing symptoms and complications. Liver transplantation may be necessary in severe cases.
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