Carbapenem

Definition

Carbapenems are a class of broad-spectrum beta-lactam antibiotics highly effective against many Gram-positive and Gram-negative bacteria. They are often used as a last resort for treating severe bacterial infections that are resistant to other antibiotics.

5 Must Know Facts For Your Next Test

1. Carbapenems inhibit bacterial cell wall synthesis by binding to penicillin-binding proteins.
2. They are resistant to most beta-lactamases, enzymes produced by bacteria that inactivate other beta-lactam antibiotics.
3. Common carbapenems include imipenem, meropenem, doripenem, and ertapenem.
4. Carbapenem-resistant Enterobacteriaceae (CRE) is an urgent public health threat due to its high level of resistance.
5. The use of carbapenems should be carefully monitored to prevent the development of drug resistance.

Related terms

Beta-Lactam Antibiotics:

A class of antibiotics that includes penicillins, cephalosporins, monobactams, and carbapenems.

Penicillin-Binding Proteins (PBPs): Proteins located in bacterial cell membranes that are targeted by beta-lactam antibiotics.

Beta-Lactamases:

Enzymes produced by some bacteria that can hydrolyze and inactivate beta-lactam antibiotics.