Arthritis

Definition

Arthritis is an inflammatory condition affecting the joints, characterized by pain and stiffness. It can be associated with immune system dysfunction, particularly in autoimmune forms.

5 Must Know Facts For Your Next Test

1. Rheumatoid arthritis (RA) is an autoimmune disorder where the immune system mistakenly attacks joint tissues.
2. Cytokines such as TNF-alpha and IL-1 play crucial roles in the inflammation seen in RA.
3. Autoantibodies like rheumatoid factor (RF) and anti-citrullinated protein antibodies (ACPAs) are often present in RA patients.
4. Certain infections can trigger reactive arthritis, a form of arthritis linked to immune response against pathogens.
5. The synovial membrane becomes inflamed in RA, leading to pannus formation which damages cartilage and bone.

Review Questions

Related terms

Autoimmunity: A condition where the immune system attacks the body's own cells.

Cytokines:

Small proteins released by cells that have a specific effect on interactions and communications between cells.

Synovial Membrane: A specialized connective tissue that lines the inner surface of capsules of synovial joints.