๐Ÿซ€Anatomy and Physiology II

Heart Valve Locations

Study smarter with Fiveable

Get study guides, practice questions, and cheatsheets for all your subjects. Join 500,000+ students with a 96% pass rate.

Get Started

Why This Matters

Heart valves control the direction of blood flow through the cardiovascular system. Understanding their locations means understanding pressure gradients, the cardiac cycle, and how valve dysfunction disrupts both pulmonary and systemic circulation. When you know where each valve sits, you can predict what happens when it fails.

The four main valves come in two functional pairs: the atrioventricular (AV) valves separate atria from ventricles, and the semilunar valves guard the exits to major arteries. This pairing reflects the heart's two-pump design: the right side handles pulmonary circulation, the left side handles systemic. Don't just memorize valve names. Know what type each valve is, which circuit it serves, and when in the cardiac cycle it opens and closes.


Atrioventricular Valves: Guarding the Atria-Ventricle Junction

The AV valves prevent backflow from ventricles into atria during ventricular systole. They're anchored by chordae tendineae and papillary muscles, which prevent the leaflets from everting (prolapsing) when ventricular pressure spikes.

Tricuspid Valve

  • Located between the right atrium and right ventricle. It's the only valve with three cusps on the right side of the heart.
  • Three leaflets (cusps) attach to chordae tendineae, which anchor to papillary muscles in the right ventricle.
  • Serves pulmonary circulation by allowing deoxygenated blood to pass into the right ventricle for delivery to the lungs.

Mitral Valve (Bicuspid Valve)

  • Located between the left atrium and left ventricle. It's the only valve in the heart with just two cusps (anterior and posterior leaflets).
  • Bicuspid structure is suited to the higher pressures of the left heart. Despite having fewer cusps, the larger leaflet surface area creates a strong seal.
  • Critical for systemic circulation because it ensures oxygenated blood moves forward into the left ventricle rather than regurgitating backward during contraction.

Compare: Tricuspid vs. Mitral: both are AV valves anchored by chordae tendineae, but the tricuspid has three cusps (right side, lower pressure) while the mitral has two cusps (left side, higher pressure). If you're asked about valve structure adaptations to pressure, contrast these two.


Semilunar Valves: Guarding the Arterial Exits

The semilunar valves prevent backflow from arteries into ventricles during ventricular diastole. Their crescent-shaped (half-moon) cusps fill with blood and snap shut when arterial pressure exceeds ventricular pressure, producing the "dub" (S2) of heart sounds.

Pulmonary Valve

  • Located between the right ventricle and pulmonary trunk. It guards the exit to pulmonary circulation.
  • Three semilunar cusps open during right ventricular systole when ventricular pressure exceeds pulmonary artery pressure (~25 mmHg systolic).
  • Closes during diastole to prevent deoxygenated blood from flowing back into the right ventricle.

Aortic Valve

  • Located between the left ventricle and aorta. This is the final checkpoint before blood enters systemic circulation.
  • Three semilunar cusps must withstand the highest pressures in the cardiovascular system (approximately 120 mmHg during systole).
  • Coronary artery ostia sit just above this valve in the aortic sinuses. That's why coronary perfusion primarily occurs during diastole, when the aortic valve closes and blood fills those sinuses.

Compare: Pulmonary vs. Aortic: both are semilunar valves with three cusps and no chordae tendineae, but the aortic valve faces much higher pressures and is more commonly affected by stenosis and calcification clinically.


Rudimentary Valves: Fetal Remnants in the Right Atrium

These structures are vestigial remnants of fetal circulation. In utero, they helped direct oxygenated blood from the placenta through the foramen ovale, bypassing the non-functional fetal lungs. In adults, they're typically non-functional.

Eustachian Valve (Valve of the Inferior Vena Cava)

  • Located at the IVC opening into the right atrium. It appears as a crescent-shaped fold of endocardium.
  • Fetal function: directed oxygenated placental blood toward the foramen ovale, shunting it from the right atrium to the left atrium.
  • Variable presence in adults. It ranges from absent to prominent but generally has no hemodynamic significance after birth.

Thebesian Valve (Valve of the Coronary Sinus)

  • Located at the coronary sinus opening into the right atrium. It covers the drainage point where coronary venous blood returns to the heart.
  • Thin, semicircular flap that may partially prevent backflow into the coronary sinus during atrial contraction.
  • Clinically relevant during cardiac catheterization procedures, particularly when accessing the coronary sinus for procedures like placing a cardiac resynchronization therapy lead.

Compare: Eustachian vs. Thebesian: both are rudimentary right atrial valves with fetal origins, but the Eustachian valve directed systemic blood flow while the Thebesian valve guards coronary venous return. Neither is essential for adult circulation.


Valve Classification: Structural and Functional Groupings

Understanding valve categories helps you answer questions about mechanisms rather than individual structures.

Atrioventricular Valves (Collective Term)

  • Includes tricuspid and mitral valves. Both prevent backflow from ventricles to atria during systole.
  • Structural features include leaflets, chordae tendineae, and papillary muscles working as a unit. The papillary muscles contract to pull the chordae taut, keeping the leaflets from flipping into the atria under pressure.
  • Produce the S1 heart sound ("lub") when they snap shut at the beginning of ventricular systole (isovolumetric contraction).

Semilunar Valves (Collective Term)

  • Includes pulmonary and aortic valves. Both prevent backflow from great vessels into ventricles.
  • No chordae tendineae. Their pocket-like cusps fill with blood and seal shut passively when arterial pressure exceeds ventricular pressure.
  • Produce the S2 heart sound ("dub") when they close at the beginning of ventricular diastole (isovolumetric relaxation).

Compare: AV valves vs. Semilunar valves: AV valves have chordae tendineae and close during systole (S1), while semilunar valves lack chordae and close during diastole (S2). This structural difference is why valve prolapse is a condition of AV valves specifically: semilunar valves don't have leaflets that can evert into a chamber.


Quick Reference Table

ConceptBest Examples
Right heart valvesTricuspid, Pulmonary
Left heart valvesMitral (Bicuspid), Aortic
AV valves (with chordae tendineae)Tricuspid, Mitral
Semilunar valves (no chordae)Pulmonary, Aortic
Three-cusped valvesTricuspid, Pulmonary, Aortic
Two-cusped valveMitral (Bicuspid)
Valves producing S1Tricuspid, Mitral
Valves producing S2Pulmonary, Aortic
Rudimentary/vestigial valvesEustachian, Thebesian

Self-Check Questions

  1. Which two valves close simultaneously to produce the S1 heart sound, and what phase of the cardiac cycle does this mark?

  2. Compare the structural support systems of AV valves versus semilunar valves. Why do only AV valves need chordae tendineae?

  3. A patient has regurgitation (backflow) from the aorta into the left ventricle. Which valve is dysfunctional, and during which phase of the cardiac cycle does this backflow occur?

  4. Both the tricuspid and mitral valves are AV valves, yet the mitral valve has only two cusps while the tricuspid has three. How might this structural difference relate to the pressure differences between the right and left sides of the heart?

  5. Trace the path of a red blood cell from the right atrium to the aorta. Which four valves does it pass through in order, and which are semilunar versus atrioventricular?