Factors of superseding cause refer to specific elements that determine whether an intervening act breaks the chain of causation in a tort case. These factors help courts assess if a defendant can still be held liable for harm caused by an intervening event that occurs after the defendant's initial act or omission. The significance of these factors lies in their ability to distinguish between what is considered a foreseeable outcome and what is so remote or extraordinary that it warrants absolving the original defendant of liability.