Gabriel amine synthesis

Definition

Gabriel amine synthesis is a method used in organic chemistry to produce primary amines from primary alkyl halides through the use of phthalimide as a nitrogen source. The process involves nucleophilic substitution followed by deprotection of the phthalimide to release the primary amine.

Related terms

Nucleophilic substitution: A reaction in which an electron-rich nucleophile selectively bonds with or attacks the positive charge of an atom or a group of atoms to replace a leaving group; essential in creating many types of chemical compounds.

Primary amine: An organic compound containing one alkyl or aryl group attached to a nitrogen atom; it's the simplest form of amines.

Deprotection:

A chemical reaction that removes protective groups from molecules, revealing their active sites for further reaction