🥼organic chemistry review

Carboxylic acid derivative

Written by the Fiveable Content Team • Last updated September 2025
Written by the Fiveable Content Team • Last updated September 2025

Definition

Carboxylic acid derivatives are compounds that contain a functional group which is a modified form of the carboxylic acid group (–COOH), where the hydroxyl part (-OH) is replaced by another atom or group of atoms. These derivatives undergo nucleophilic acyl substitution reactions, where an electron-rich nucleophile attacks the carbonyl carbon, leading to the substitution of the leaving group.