The Indian Removal Era refers to a period in the early to mid-19th century characterized by the forced relocation of Native American tribes from their ancestral homelands, primarily in the southeastern United States, to designated Indian Territory west of the Mississippi River. This era was marked by policies enacted by the U.S. government aimed at opening up land for European-American settlers and was driven by a mix of economic interests, racial ideologies, and the belief in Manifest Destiny.