Uridine

Definition

Uridine is a nucleoside composed of uracil and ribose, playing a crucial role in RNA synthesis. It also serves as a precursor for the synthesis of pyrimidine nucleotides.

5 Must Know Facts For Your Next Test

1. Uridine is essential for RNA transcription and cellular energy metabolism.
2. It can be phosphorylated to form uridine monophosphate (UMP), which is pivotal in nucleotide biosynthesis.
3. Uridine analogs are used in antiviral and anticancer therapies due to their ability to inhibit RNA-dependent processes.
4. Some antimicrobial drugs target enzymes involved in uridine metabolism, disrupting pathogen replication.
5. Deficiency or imbalance in uridine levels can lead to metabolic disorders and impact DNA repair mechanisms.

Review Questions

• What role does uridine play in RNA synthesis?
• How do uridine analogs contribute to antiviral treatments?
• Why is the regulation of uridine metabolism important for antimicrobial drug mechanisms?

Related terms

Nucleoside: A molecule consisting of a nitrogenous base bound to a sugar.

RNA Polymerase: An enzyme that synthesizes RNA from a DNA template.

Pyrimidine Nucleotides: Building blocks for nucleic acids, including cytosine, thymine, and uracil derivatives.