TMP/SMZ, also known as Trimethoprim/Sulfamethoxazole, is a combination antibiotic used to treat various bacterial infections. It inhibits bacterial synthesis of folic acid, essential for DNA replication and cell survival.
5 Must Know Facts For Your Next Test
TMP/SMZ is effective against a broad spectrum of Gram-positive and Gram-negative bacteria.
It is commonly used to treat skin infections, such as MRSA (Methicillin-resistant Staphylococcus aureus).
This antibiotic combination is also used for gastrointestinal infections like traveler's diarrhea caused by E. coli.
TMP/SMZ works synergistically by inhibiting two consecutive steps in the bacterial folate synthesis pathway.
Patients with a sulfa allergy should avoid TMP/SMZ due to potential severe allergic reactions.
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Related terms
Folate Synthesis Pathway: A biochemical pathway that produces folic acid, which is essential for DNA synthesis in bacteria.