Tetanus toxin

Definition

Tetanus toxin, also known as tetanospasmin, is a potent neurotoxin produced by the bacterium Clostridium tetani. It disrupts neurotransmitter release, causing muscle stiffness and spasms characteristic of tetanus.

5 Must Know Facts For Your Next Test

1. Tetanus toxin inhibits the release of inhibitory neurotransmitters like glycine and GABA.
2. The toxin is produced under anaerobic conditions within contaminated wounds.
3. It travels along peripheral nerves to the central nervous system where it exerts its effects.
4. Vaccination with tetanus toxoid is an effective preventive measure against tetanus.
5. Treatment often involves administration of antitoxin and wound care to remove the source of bacterial spores.

Review Questions

Related terms

Neurotoxin: A poison that acts on the nervous system.

Clostridium tetani:

A type of bacteria that produces tetanus toxin.

Tetanus toxoid vaccine: An immunization method using an inactivated form of the toxin to prevent tetanus.