Synergistic interaction
from class: Microbiology Definition Synergistic interaction occurs when two or more antimicrobial drugs work together to produce a stronger effect than the sum of their individual effects. This can lead to more effective treatment of infections and reduced resistance development.
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Predict what's on your test 5 Must Know Facts For Your Next Test Synergistic interactions can significantly lower the required dosage of each drug, minimizing potential side effects. Common examples include the combination of Trimethoprim and Sulfamethoxazole. Such interactions are particularly beneficial in treating multi-drug resistant bacterial infections. Synergy is often assessed using methods like checkerboard assays and time-kill curves. Not all drug combinations are synergistic; some can be antagonistic, reducing overall effectiveness. Review Questions What is the main benefit of combining antimicrobial drugs in a synergistic interaction? How do synergistic interactions help in combating antibiotic resistance? Name one method used to assess synergistic interactions between antimicrobial drugs.
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