Stibogluconate
from class: Microbiology Definition Stibogluconate is an antimonial compound used to treat leishmaniasis, a parasitic disease affecting the circulatory and lymphatic systems. It interferes with parasite metabolism, leading to their death.
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Predict what's on your test 5 Must Know Facts For Your Next Test Stibogluconate is primarily used in the treatment of visceral and cutaneous leishmaniasis. It is administered intravenously or intramuscularly over a course of several weeks. The drug works by inhibiting glycolysis and fatty acid oxidation in the parasite. Common side effects include nausea, vomiting, muscle pain, and liver enzyme abnormalities. Resistance to stibogluconate has been reported in certain regions, necessitating alternative treatments. Review Questions What types of leishmaniasis are treated with stibogluconate? How does stibogluconate affect the metabolism of Leishmania parasites? What are some common side effects associated with stibogluconate treatment?
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