Written by the Fiveable Content Team • Last updated September 2025
Written by the Fiveable Content Team • Last updated September 2025
Definition
St. Louis encephalitis (SLE) is a viral disease that causes inflammation of the brain and is transmitted by mosquitoes. It predominantly affects individuals in North America, particularly in the United States.
5 Must Know Facts For Your Next Test
SLE is caused by the St. Louis encephalitis virus (SLEV), a member of the Flavivirus genus.
The primary vectors for SLEV transmission are Culex mosquitoes.
Symptoms of SLE can range from mild flu-like illness to severe neurological conditions, including encephalitis, coma, or death.
There is no specific antiviral treatment for SLE; management focuses on supportive care to relieve symptoms.
Older adults and those with weakened immune systems are at higher risk for severe complications from SLE.
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Related terms
West Nile Virus: A flavivirus transmitted by mosquitoes that can cause similar neurological diseases as SLE.
Japanese Encephalitis: A viral infection spread by mosquitoes in Asia that also causes brain inflammation.