Written by the Fiveable Content Team • Last updated September 2025
Written by the Fiveable Content Team • Last updated September 2025
Definition
The smooth endoplasmic reticulum (SER) is an organelle in eukaryotic cells involved in lipid synthesis, detoxification, and calcium ion storage. Unlike the rough endoplasmic reticulum, it lacks ribosomes on its surface.
5 Must Know Facts For Your Next Test
SER plays a crucial role in the synthesis of lipids and steroids.
It is involved in detoxifying chemicals and metabolizing drugs within liver cells.
SER regulates calcium ion concentration, especially in muscle cells for contraction.
It helps transport synthesized lipids to other parts of the cell.
Unlike rough ER, SER does not have ribosomes attached to its membrane.
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Related terms
Rough Endoplasmic Reticulum (RER): An organelle with ribosomes on its surface, involved in protein synthesis.