Serum Amyloid A (SAA) is an acute-phase protein produced primarily by the liver in response to inflammation. It plays a role in modulating the immune response and can act as a chemoattractant for immune cells.
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SAA levels increase rapidly in response to inflammation or infection, often within hours.
It assists in the recruitment of immune cells to sites of injury or infection.
SAA can bind to high-density lipoproteins (HDL), transporting them to sites of inflammation.
Chronic elevation of SAA is associated with diseases such as rheumatoid arthritis and coronary artery disease.
SAA's role includes promoting the clearance of apoptotic cells and inhibiting microbial growth.
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Related terms
Acute-Phase Protein: Proteins whose plasma concentrations increase or decrease in response to inflammation.
Chemoattractant: Substances that attract immune cells to sites of infection or damage.