Secretory IgA
from class: Microbiology Definition Secretory IgA (sIgA) is an immunoglobulin found predominantly in mucosal areas, such as the gut, respiratory tract, and urogenital tract. It plays a crucial role in immune function by preventing colonization by pathogens.
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Predict what's on your test 5 Must Know Facts For Your Next Test sIgA is the main antibody found in mucosal secretions like saliva, tears, and breast milk. It is composed of two IgA molecules linked by a J chain and a secretory component. sIgA provides immunity without causing inflammation, which is critical for protecting mucosal surfaces. Deficiency in sIgA can lead to increased susceptibility to infections on mucosal surfaces. sIgA interacts with antigens and pathogens to neutralize them before they penetrate the body's tissues. Review Questions What is the primary role of secretory IgA in the immune system? Where are high concentrations of sIgA typically found within the body? How does sIgA contribute to immune defense without causing inflammation? "Secretory IgA" also found in:
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