Rickettsia typhi

Definition

Rickettsia typhi is a gram-negative, obligate intracellular bacterium that causes murine typhus. It is typically transmitted to humans through the bite of infected fleas.

5 Must Know Facts For Your Next Test

1. Rickettsia typhi primarily infects endothelial cells lining blood vessels, leading to vasculitis.
2. Common symptoms of Rickettsia typhi infection include fever, headache, rash, and muscle pain.
3. The primary reservoir for Rickettsia typhi is rodents, especially rats.
4. Murine typhus is often diagnosed using serological tests such as the Weil-Felix test or indirect immunofluorescence assay (IFA).
5. Treatment for infections caused by Rickettsia typhi typically involves antibiotics such as doxycycline.

Review Questions

Related terms

Weil-Felix test: A serological test used to diagnose rickettsial infections by detecting cross-reacting antibodies.

Doxycycline:

An antibiotic commonly used to treat bacterial infections, including those caused by Rickettsia species.

Endothelial cells: Cells that line the interior surface of blood vessels and lymphatic vessels.