Replication bubble

Definition

A replication bubble is a region of DNA where the double helix has unwound and opened to allow for replication. It forms at the origin of replication and includes two replication forks moving in opposite directions.

5 Must Know Facts For Your Next Test

1. Replication bubbles are essential structures in DNA replication, ensuring that the entire genome is copied accurately.
2. Each replication bubble contains two replication forks that move away from each other as replication progresses.
3. The formation of a replication bubble starts at specific sequences called origins of replication.
4. Multiple replication bubbles can form simultaneously along eukaryotic chromosomes to speed up the process of DNA replication.
5. Proteins such as helicases, single-strand binding proteins, and DNA polymerases play critical roles within the replication bubble.

Review Questions

• What initiates the formation of a replication bubble?
• How many replication forks are present in a single replication bubble?
• Why are multiple replication bubbles important for eukaryotic cells?

Related terms

Origin of Replication: Specific sequence where DNA unwinding begins to form a replication bubble.

Helicase: An enzyme that unwinds the DNA double helix within the replication bubble.

Replication Fork: The Y-shaped structure formed by the unwound DNA strands where new DNA synthesis occurs.