Polymyxin B is an antibiotic primarily used to treat Gram-negative bacterial infections. It disrupts the bacterial cell membrane, leading to cell death.
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Polymyxin B is particularly effective against Pseudomonas aeruginosa, a common pathogen in skin and eye infections.
It is often used in topical formulations, such as ointments and eye drops, due to its nephrotoxicity when administered systemically.
Polymyxin B works by binding to the lipopolysaccharides in the outer membrane of Gram-negative bacteria.
Resistance to Polymyxin B can occur but is relatively rare compared to other antibiotics.
Combination therapy with other antibiotics may be employed to enhance efficacy and reduce resistance development.
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Related terms
Neomycin: An antibiotic used in combination with Polymyxin B for treating skin infections.
Gram-negative bacteria: A class of bacteria characterized by a thin peptidoglycan layer and an outer membrane containing lipopolysaccharides.