Phospholipase A

Definition

Phospholipase A is an enzyme that hydrolyzes the sn-2 acyl bond of phospholipids, releasing fatty acids and lysophospholipids. It plays a role in bacterial pathogenesis by disrupting host cell membranes.

5 Must Know Facts For Your Next Test

1. Phospholipase A is important for the virulence of certain uropathogenic bacteria.
2. This enzyme disrupts host cell membranes, aiding bacterial invasion and infection.
3. It can trigger inflammatory responses in the host's urinary tract.
4. Inhibition of phospholipase A activity can reduce bacterial virulence.
5. Some bacteria produce multiple types of phospholipase A to enhance their infectious capabilities.

Review Questions

• What role does phospholipase A play in bacterial infections of the urinary system?
• How does phospholipase A contribute to the pathogenicity of uropathogenic bacteria?
• What is the result of inhibiting phospholipase A activity in bacterial infections?

Related terms

Uropathogenic Bacteria: Bacteria that cause infections in the urinary tract.

Pathogenesis: The process by which a disease develops and progresses.

Lysophospholipid: A product formed when phospholipase A hydrolyzes a phospholipid, involved in signaling and membrane dynamics.