Pentameric IgM

Definition

Pentameric IgM is an immunoglobulin composed of five IgM monomers linked together, forming a large, complex structure. It plays a crucial role in the initial stages of the immune response by effectively binding to antigens and activating complement pathways.

5 Must Know Facts For Your Next Test

1. Pentameric IgM has a high avidity for antigens due to its multiple binding sites.
2. It is the first antibody isotype produced during a primary immune response.
3. Pentameric IgM is primarily found in the blood and lymphatic fluid.
4. IgM can activate the classical complement pathway, leading to pathogen destruction.
5. IgM is effective in agglutinating pathogens, making them easier targets for phagocytosis.

Review Questions

Related terms

B Lymphocytes:

White blood cells that produce antibodies and are essential for adaptive immunity.

Humoral Immunity:

The aspect of immunity that involves antibodies secreted by B cells targeting extracellular pathogens.

Complement Pathway: A system of plasma proteins that enhances the ability of antibodies to clear pathogens from an organism.