Orfloxacin

Definition

Ofloxacin is a broad-spectrum antibiotic belonging to the fluoroquinolone class, used to treat various bacterial infections. It works by inhibiting bacterial DNA gyrase and topoisomerase IV.

5 Must Know Facts For Your Next Test

1. Ofloxacin is effective against both Gram-positive and Gram-negative bacteria.
2. Common side effects include nausea, diarrhea, and dizziness.
3. It is often used to treat gastrointestinal infections caused by bacteria like Salmonella and Shigella.
4. Ofloxacin can lead to the development of antibiotic-resistant bacteria if misused or overused.
5. The drug should not be taken with antacids containing magnesium or aluminum as they can interfere with its absorption.

Review Questions

Related terms

Fluoroquinolones:

A class of antibiotics that includes drugs like ciprofloxacin and levofloxacin.

DNA Gyrase:

An enzyme targeted by fluoroquinolones to inhibit bacterial DNA replication.

Antibiotic Resistance:

The ability of bacteria to withstand the effects of an antibiotic that once could successfully treat the infection.