Omeprazole

Definition

Omeprazole is a proton pump inhibitor (PPI) used to reduce stomach acid production. It is often prescribed for conditions like gastroesophageal reflux disease (GERD) and peptic ulcers.

5 Must Know Facts For Your Next Test

1. Omeprazole inhibits the H+/K+ ATPase enzyme system of gastric parietal cells, reducing acid secretion.
2. It is commonly used to treat Helicobacter pylori infections when combined with antibiotics.
3. Long-term use of omeprazole can lead to vitamin B12 deficiency and increased risk of gastrointestinal infections.
4. The medication is metabolized primarily in the liver by the cytochrome P450 enzyme system, particularly CYP2C19.
5. Omeprazole can interfere with the absorption of drugs that require an acidic environment for optimal absorption.

Review Questions

• What enzyme does omeprazole inhibit to reduce stomach acid production?
• How does omeprazole treatment relate to Helicobacter pylori infections?
• What are some potential risks associated with long-term use of omeprazole?

Related terms

Proton Pump Inhibitor (PPI): A class of medications that reduce stomach acid production by blocking the H+/K+ ATPase enzyme.

Gastroesophageal Reflux Disease (GERD): A chronic condition where stomach acid frequently flows back into the esophagus, causing irritation.

Helicobacter pylori:

A type of bacteria that infects the stomach lining and is associated with peptic ulcers and certain types of gastritis.