🦠microbiology review

Megasphaera

Written by the Fiveable Content Team • Last updated September 2025
Written by the Fiveable Content Team • Last updated September 2025

Definition

Megasphaera is a genus of anaerobic, Gram-negative bacteria commonly found in the human urogenital tract. These bacteria are part of the normal microbiota but can become pathogenic under specific conditions.

5 Must Know Facts For Your Next Test

  1. Megasphaera species are anaerobic, meaning they thrive in environments without oxygen.
  2. These bacteria are Gram-negative and have a spherical shape.
  3. Megasphaera is often found in the normal flora of the female vaginal microbiota.
  4. An imbalance in Megasphaera populations can be associated with bacterial vaginosis.
  5. Megasphaera elsdenii is one of the well-studied species within this genus.

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