Mannose-binding lectin

Definition

Mannose-binding lectin (MBL) is a protein that binds to mannose residues on the surface of pathogens, leading to their recognition and elimination by the immune system. It plays a crucial role in the innate immune response by activating the complement system.

5 Must Know Facts For Your Next Test

1. MBL is part of the lectin pathway of the complement system.
2. It recognizes carbohydrate patterns on pathogens, such as bacteria, viruses, and fungi.
3. MBL deficiency can increase susceptibility to infections.
4. Upon binding to a pathogen, MBL activates MASPs (MBL-associated serine proteases), which then trigger the complement cascade.
5. It is considered a first-line defense mechanism due to its ability to recognize pathogens without prior exposure.

Review Questions

Related terms

Complement System:

A group of proteins that work together to destroy pathogens and signal other immune cells.

Lectin Pathway:

One of three pathways that activate the complement system; initiated by mannose-binding lectin recognizing pathogen surfaces.

MASPs: Serine proteases associated with MBL that trigger downstream complement activation upon pathogen binding.