Malarone

Definition

Malarone is a combination antimicrobial drug containing atovaquone and proguanil, used primarily for the prevention and treatment of malaria. It works by inhibiting mitochondrial electron transport in the parasite and disrupting folate synthesis.

5 Must Know Facts For Your Next Test

1. Malarone is effective against Plasmodium falciparum, the most dangerous malaria parasite.
2. The combination of atovaquone and proguanil targets two different biochemical pathways within the parasite.
3. It is typically taken once daily for both prevention and treatment purposes.
4. Malarone has fewer side effects compared to other antimalarial drugs like mefloquine or chloroquine.
5. Resistance to Malarone is relatively low but can develop if not taken as prescribed.

Review Questions

• What are the two active components of Malarone?
• How does Malarone work to inhibit malaria parasites?
• Why might Malarone be preferred over other antimalarial drugs?

Related terms

Atovaquone: An antimicrobial medication that inhibits mitochondrial electron transport in parasites.

Proguanil: A drug that interferes with folate synthesis in malaria parasites, enhancing the effectiveness of atovaquone.

Plasmodium falciparum: The most dangerous species of Plasmodium responsible for severe cases of malaria.