key term - Major basic protein (MBP)

Definition

Major basic protein (MBP) is a cationic protein found in the granules of eosinophils. It plays a crucial role in immune defense by combating parasites and contributing to allergic reactions.

5 Must Know Facts For Your Next Test

1. MBP is toxic to parasites, such as helminths, by damaging their outer membranes.
2. High levels of MBP are associated with allergic reactions and asthma due to its ability to cause tissue damage.
3. MBP can stimulate the release of histamine from mast cells and basophils, enhancing inflammation.
4. It has antimicrobial properties against some bacteria and viruses, contributing to innate immunity.
5. MBP is involved in the modulation of immune responses by interacting with other immune cells.

Review Questions

Related terms

Eosinophil: A type of white blood cell involved in combating multicellular parasites and certain infections.

Histamine:

A compound released by mast cells that causes vasodilation and increased permeability during inflammatory responses.

Innate Immunity:

The body's first line of defense against pathogens, involving nonspecific physical and chemical barriers.