Lumefantrine

Definition

Lumefantrine is an antimalarial drug used in combination with artemether to treat acute uncomplicated malaria caused by Plasmodium falciparum. It interferes with the conversion of heme to hemozoin, which is toxic to the malaria parasite.

5 Must Know Facts For Your Next Test

1. Lumefantrine is often used in combination with artemether, forming a potent treatment known as ACT (Artemisinin-based Combination Therapy).
2. It primarily targets the blood stages of Plasmodium falciparum, disrupting the parasite's ability to detoxify heme.
3. Lumefantrine has a long half-life, which helps prevent recurrence of the infection.
4. The drug is metabolized in the liver and can have interactions with other medications metabolized by cytochrome P450 enzymes.
5. Common side effects can include headache, dizziness, and gastrointestinal disturbances.

Review Questions

• What is the primary mechanism by which lumefantrine acts against Plasmodium falciparum?
• Why is lumefantrine often combined with artemether in malaria treatment?
• What are some common side effects associated with lumefantrine?

Related terms

Artemether: An antimalarial drug that acts quickly against blood-stage Plasmodium parasites.

Plasmodium falciparum: The most dangerous species of Plasmodium that causes severe and often fatal malaria.

Cytochrome P450: A family of enzymes involved in drug metabolism that can interact with lumefantrine.