Leukotrienes are lipid-based chemical mediators derived from arachidonic acid, involved in the inflammatory response. They play a significant role in immune responses, particularly in allergic reactions and asthma.
5 Must Know Facts For Your Next Test
Leukotrienes are produced by leukocytes and are involved in the pathophysiology of asthma.
They increase vascular permeability, leading to edema during inflammation.
Leukotrienes cause contraction of bronchial smooth muscles, contributing to bronchoconstriction.
LTC4, LTD4, and LTE4 are types of cysteinyl leukotrienes that promote inflammation and hypersensitivity.
Inhibitors of leukotriene synthesis or action, such as montelukast, are used in the treatment of asthma.
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Related terms
Arachidonic Acid: A polyunsaturated fatty acid that is a precursor to various eicosanoids including leukotrienes.