Leukocidins

Definition

Leukocidins are toxins produced by certain bacteria that kill white blood cells, thereby weakening the host's immune response. They are important virulence factors in many pathogenic bacteria.

5 Must Know Facts For Your Next Test

1. Leukocidins target and lyse white blood cells, primarily neutrophils and macrophages.
2. Staphylococcus aureus and Streptococcus pyogenes are notable producers of leukocidins.
3. Leukocidins contribute to the formation of pus by killing white blood cells at infection sites.
4. The Panton-Valentine leukocidin (PVL) is a well-known example associated with severe skin infections.
5. Leukocidins disrupt the host's immune defenses, facilitating bacterial survival and spread.

Related terms

Panton-Valentine Leukocidin (PVL): A specific type of leukocidin associated with Staphylococcus aureus that causes severe skin infections.

Virulence Factors:

Molecules produced by pathogens that contribute to their ability to cause disease.

Neutrophils:

A type of white blood cell that is one of the first responders to microbial infection.