Leukocidin

Definition

Leukocidin is a type of cytotoxin created by certain bacteria that can kill white blood cells, thereby weakening the immune response. It is often associated with Staphylococcus aureus and Streptococcus species.

5 Must Know Facts For Your Next Test

1. Leukocidins are produced primarily by pathogenic bacteria such as Staphylococcus aureus and Streptococcus pyogenes.
2. These toxins work by forming pores in the membranes of leukocytes (white blood cells), leading to cell lysis and death.
3. Leukocidins play a significant role in helping bacteria evade the host's immune system.
4. Panton-Valentine leukocidin (PVL) is a well-known type of leukocidin associated with severe skin infections and pneumonia.
5. The presence of leukocidins can complicate infections and make them more difficult to treat.

Related terms

Cytotoxin: A substance toxic to cells, causing their damage or death.

Staphylococcus aureus:

A gram-positive bacterium often involved in skin infections and capable of producing various toxins including leukocidins.

Pore-forming toxins: A class of proteins that create pores in cell membranes, leading to cell lysis.