Written by the Fiveable Content Team • Last updated September 2025
Written by the Fiveable Content Team • Last updated September 2025
Definition
L-form bacteria are variant forms of bacteria that lack a cell wall. They can arise naturally or be induced in the laboratory by exposure to antibiotics or other stressors.
5 Must Know Facts For Your Next Test
L-form bacteria can survive without a rigid cell wall, unlike most typical bacterial forms.
They were first discovered in the bacterium Streptobacillus moniliformis and are named after the Lister Institute where they were identified.
L-forms can revert back to their original walled state under certain conditions.
These forms are often resistant to antibiotics that target cell wall synthesis, such as penicillin.
Research into L-forms helps scientists understand antibiotic resistance and the mechanisms of bacterial adaptation.
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Related terms
Protoplast: A bacterial or plant cell with its cell wall removed.
Spheroplast: A gram-negative bacterium whose peptidoglycan layer has been partially removed.