IgA1 protease

Definition

IgA1 protease is an enzyme produced by certain bacteria that cleaves IgA1 antibodies, aiding in immune evasion. It plays a critical role in the pathogenesis of bacterial infections, particularly those affecting mucosal surfaces.

5 Must Know Facts For Your Next Test

1. IgA1 protease specifically targets the hinge region of IgA1 antibodies, impairing their function.
2. Neisseria meningitidis and Haemophilus influenzae are notable bacteria that produce IgA1 protease.
3. By degrading IgA1 antibodies, the enzyme helps pathogens evade the host's immune system.
4. The action of IgA1 protease is crucial for bacterial colonization and infection persistence in mucosal areas.
5. IgA1 protease production is a factor contributing to the virulence of meningitis-causing bacteria.

Review Questions

Related terms

Neisseria meningitidis:

A bacterium that causes meningitis and produces IgA1 protease.

Haemophilus influenzae:

Another bacterium involved in nervous system infections known to secrete IgA1 protease.

Virulence Factor: Any molecule produced by a pathogen that contributes to its ability to cause disease.