Written by the Fiveable Content Team • Last updated September 2025
Written by the Fiveable Content Team • Last updated September 2025
Definition
Herpes simplex virus type 1 (HSV-1) is a contagious virus that predominantly causes oral herpes, leading to cold sores and fever blisters around the mouth. It can be transmitted through direct contact with infected saliva or lesions.
5 Must Know Facts For Your Next Test
HSV-1 commonly manifests as cold sores or fever blisters on the lips and around the mouth.
The virus remains dormant in nerve cells and can reactivate due to triggers such as stress or a weakened immune system.
HSV-1 infection is lifelong, with periodic outbreaks following initial infection.
Diagnosis of HSV-1 can be made through clinical observation, PCR testing, or viral cultures from lesion swabs.
Treatment primarily focuses on antiviral medications like acyclovir to reduce outbreak severity and frequency.
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Related terms
Herpes Simplex Virus Type 2 (HSV-2): A related virus that typically causes genital herpes.
Antiviral Medications: Drugs used to treat viral infections by inhibiting their development.
Cold Sores: Painful blisters caused by HSV-1, usually appearing around the mouth.