Graft

Definition

A graft is a tissue or organ transferred from one site to another, either within the same individual or between donor and recipient. It plays a crucial role in organ transplantation.

5 Must Know Facts For Your Next Test

1. Grafts can be classified as autografts, allografts, xenografts, and isografts depending on the source.
2. Allograft rejection is primarily mediated by the recipient's immune system recognizing the graft as foreign.
3. Immunosuppressive drugs are critical in preventing graft rejection by inhibiting immune responses.
4. Histocompatibility antigens, particularly those of the major histocompatibility complex (MHC), play a key role in graft acceptance or rejection.
5. Chronic rejection can occur months to years after transplantation and may lead to graft failure.

Review Questions

Related terms

Autograft: A graft taken from one part of the body and transplanted to another site within the same individual.

Allograft: A graft transplanted between genetically non-identical individuals of the same species.

Immunosuppression:

The reduction of immune response efficacy, often achieved through medication to prevent transplant rejection.